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John P. Case, MD  


Internal Medicine, Rheumatology


John H. Stroger, Jr. Hospital



Faculty Rank:

Senior Staff Physician

Board Certification:

American Board of Internal Medicine (Rheumatology, Medicine)

Medical Education:

Tufts University School of Medicine


Rush University Medical Center


Arthritis & Rheumatism Branch, National Institute of Arthritis, Musculoskeletal & Skin Diseases, National Institutes of Health

Clinical Expertise:

Rheumatoid arthritis, gout, general rheumatology


1. Case, J. P. 1987. Keeping up with the medical literature (letter). Ann. Intern. Med. 106:481. 2. Sano H, Hla T, Maier JA et al. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J Clin Invest. 1992;89: 97-108. 3. Wilder RL, Case JP, Crofford LJ et al. Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats. J Cell Biochem. 1991;45: 162-166. 4. Lorberboum-Galski H, Lafyatis R, Case JP, FitzGerald D, Wilder RL, Pastan I. Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion. Int J Immunopharmacol. 1991;13: 305-315. 5. Remmers EF, Sano H, Lafyatis R et al. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. J Rheumatol. 1991;18: 7-13. 6. Wilder RL, Remmers EF, Sano H, Case JP, Lafyatis R. The cytokine network in rheumatoid arthritis. Br J Rheumatol. 1991;30 Suppl 2: 44-47. 7. Case JP, Lafyatis R, Kumkumian GK, Remmers EF, Wilder, RL. IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway. J Immunol. 1990;145: 3755-3761. 8. Wilder RL, Lafyatis R, Roberts AB et al. Transforming growth factor-beta in rheumatoid arthritis. Ann N Y Acad Sci. 1990;593: 197-207. 9. Remmers EF, Lafyatis R, Kumkumian GK et al. Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis. Growth Factors. 1990;2: 179-188. 10. Leff RL, Case JP. Rheumatoid arthritis, methotrexate therapy, and Pneumocystis pneumonia. Ann Intern Med. 1990;112: 716. 11. Sano H, Forough R, Maier JA et al. Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints. J Cell Biol. 1990;110: 1417-1426. 12. Wilder RL, Lafyatis R, Yocum DE, Case JP, Kumkumian GK, Remmers EF. Mechanisms of bone and cartilage destruction in rheumatoid arthritis: lessons from the streptococcal cell wall arthritis model in LEW/N rats. Clin Exp Rheumatol. 1989;7 Suppl 3: S123-S127. 13. Case JP, Lafyatis R, Remmers EF, Kumkumian GK, Wilder, RL. Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol. 1989;135: 1055-1064. 14. Case JP, Sano H, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL. Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats. J Clin Invest. 1989;84: 1731-1740. 15. Lafyatis R, Thompson NL, Remmers EF et al. Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization. J Immunol. 1989;143: 1142-1148. 16. Kumkumian GK, Lafyatis R, Remmers EF, Case JP, Kim SJ, Wilder RL. Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J Immunol. 1989;143: 833-837. 17. Case JP, Lorberboum-Galski H, Lafyatis R, FitzGerald D, Wilder RL, Pastan I. Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats. Proc Natl Acad Sci USA. 1989;86: 287-291. 18. Case JP. Old and new drugs used in rheumatoid arthritis: A historical perspective. Part I: The older drugs. Am J Therapeutics. 2001;8: 123-143. 19. Case JP. Old and new drugs used in rheumatoid arthritis: A historical perspective. Part II: The newer drugs and drug strategies. Am J Therapeutics. 2001;8: 163-179. 20. Hurwitz DE, Ryals AR, Case JP, Block JA, Andriacchi TP. The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and pain. J Orthop Res. 2002;20: 101-107. 21. Baliunas AJ, Hurwitz DE, Ryals AR et al. Increased knee joint loads during walking are present in subjects with knee osteoarthritis. Osteoarthritis Cartilage. 2002;10: 573-579. 22. Case, J. P., Baliunas, A. J., and Block, J. A. Lack of efficacy of acetaminophen in symptomatic knee osteoarthritis. a randomized, double-blind, placebo-controlled comparison trial with diclofenac. Arch Intern Med . 2003. 163(2):169-78. 23. Shakoor, N., Block, J. A., Shott, S., and Case, J. P. Non-random evolution of endstage osteoarthritis of the lower limbs. Arthritis Rheum. 2002. 46(12):3185-9. 24. Shakoor N. Hurwitz DE. Block JA. Shott S. Case J.P. Asymmetric knee loading in advanced unilateral hip osteoarthritis. Arthritis Rheum. 2003. 48(6):1556-61. 25. Aggarwal R, Lebiedz-Odrobina D, Sinha A, Manadan A, Case JP.Serum Cardiac Troponin T but not Troponin I, is elevated in Idiopathic Inflammatory Myopathies. J Rheumatol. 2009. 36(12):2711-14. 26. Dua, A, Manadan A, Case JP. Adult Onset Still’s Disease Presenting with Acute Respiratory Distress Syndrome: Case Report and Review of the Literature. 2013. Open Rheumatology Journal 7:125-128

Research Interests:

Rheumatoid arthritis, the elbow in arthritis, disease quantitation